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Tubulin/HDAC-IN-3
Tubulin/HDAC-IN-3
SKU:QM-0068453
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Quantity
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Product Details
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Description
Tubulin/HDAC-IN-3 (compound 12a) is a potent tubulin/HDAC dual inhibitor. Tubulin/HDAC-IN-3 effectively disrupts tubulin polymerization (IC50: 5.4 μM) . Tubulin/HDAC-IN-3 exhibits potent HDAC1/8 inhibitory activities, with IC50 values of 0.155 and 0.177 μM, respectively. Tubulin/HDAC-IN-3 works through blocking cellular cycle, inducing apoptosis and inhibiting colony formation[1].
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Molecular Formula
C28H28N2O10
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Molecular Weight
552.53
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Smiles
O=C1[C@@H](COC(C2=CC=C(C(NO)=O)C=C2)=O)[C@H](C3=CC=C(OC)C(O)=C3)N1C4=CC(OC)=C(OC)C(OC)=C4
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Target
HDAC; Microtubule/Tubulin
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Isoform
HDAC1; HDAC6; HDAC8
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Tubulin/HDAC-IN-3
Tubulin/HDAC-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.