Tubulin/HDAC-IN-4
Tubulin/HDAC-IN-4
SKU:QM-0121337
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Product Details
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Description
Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC50 values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity[1].
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Molecular Formula
C24H26N2O6
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Molecular Weight
438.47
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Smiles
CC1(C)OC2=C(C(/C=C/C3=CC=C(OC)C(NCC(NO)=O)=C3)=O)C=CC(OC)=C2C=C1
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Target
Apoptosis; HDAC; Microtubule/Tubulin; Reactive Oxygen Species (ROS)
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Isoform
HDAC1; HDAC2; HDAC6; HDAC7
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Tubulin/HDAC-IN-4
Tubulin/HDAC-IN-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.