Tubulin/NEDDylation-IN-1
Tubulin/NEDDylation-IN-1
SKU:QM-0153500-01
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Product Details
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Description
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin) -NEDDylation (IC50 for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization[1].
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Molecular Formula
C25H32N2O5S2
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Molecular Weight
504.66
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Smiles
O=C(N(CC1=CC=C(OC)C=C1)C2=CC(OC)=C(OC)C(OC)=C2)CSC(N3CCCCC3)=S
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Target
Microtubule/Tubulin
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Purity
98.03
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Tubulin/NEDDylation-IN-1
Tubulin/NEDDylation-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.