Tubulin polymerization-IN-59
Tubulin polymerization-IN-59
SKU:QM-0152319-01
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Product Details
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Description
Tubulin polymerization-IN-59 is a tubulin polymerization inhibitor and colchicine binding site inhibitor (CBSI) (IC50 = 6.1 μM) . Tubulin polymerization-IN-59 exerts potent antiproliferative activity against cancer cells, while showing lower cytotoxicity to normal cells. Tubulin polymerization-IN-59 arrests colorectal cancer HCT 116 cells in G2/M phase, induces cell apoptosis, and suppresses tumor cell colony formation and migration. Tubulin polymerization-IN-59 can be used for the study of colorectal cancer (CRC) [1].
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Molecular Formula
C20H21FO5
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Molecular Weight
360.38
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Smiles
CCOC1=CC=C(C=C1F)[C@H]2CC(C3=CC(OC)=C(C(OC)=C32)OC)=O
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Target
Apoptosis; Microtubule/Tubulin
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Purity
99.85
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Solubility
DMSO : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Tubulin polymerization-IN-59
Tubulin polymerization-IN-59 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.