Tuspetinib (dihydrochloride) [CAS 3037216-20-6]
Tuspetinib (dihydrochloride) [CAS 3037216-20-6]
SKU:QM-0007052
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Product Details
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Description
Tuspetinib (HM43239) dihydrochloride is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib dihydrochloride inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3].
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CAS Number
[3037216-20-6]
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Molecular Formula
C29H35Cl3N6
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Molecular Weight
573.99
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Smiles
ClC1=CN=C(NC2=CC(C3CC3)=CC(CN4C[C@H](N[C@H](C4)C)C)=C2)N=C1C5=CNC6=CC(C)=CC=C56.Cl.Cl
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Target
Apoptosis; FLT3
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Shipping Conditions
Room temperature
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Tuspetinib (dihydrochloride) [CAS 3037216-20-6]
Tuspetinib (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.