Umbralisib (hydrochloride) [CAS 1532533-78-0]
Umbralisib (hydrochloride) [CAS 1532533-78-0]
SKU:QM-0140668-01
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Product Details
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Description
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach[1][2][3][4].
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CAS Number
[1532533-78-0]
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Molecular Formula
C31H25ClF3N5O3
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Molecular Weight
608.01
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Smiles
O=C1C(C2=CC=CC(F)=C2)=C([C@@H](N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)C)OC6=CC=C(F)C=C16.[H]Cl
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Target
Casein Kinase; PI3K
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Isoform
CK1; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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Purity
99.04
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Solubility
DMSO : ≥ 150 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Umbralisib (hydrochloride) [CAS 1532533-78-0]
Umbralisib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.