UNC9994 (hydrochloride) [CAS 2108826-33-9]
UNC9994 (hydrochloride) [CAS 2108826-33-9]
SKU:QM-0077342-01
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Product Details
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Description
UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity[1].
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CAS Number
[2108826-33-9]
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Molecular Formula
C21H23Cl3N2OS
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Molecular Weight
457.84
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Smiles
ClC1=C(Cl)C(C2CCN(CCCOC3=CC=C(SC=N4)C4=C3)CC2)=CC=C1.Cl
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Target
5-HT Receptor; Arrestin; Dopamine Receptor
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Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; mLAG-3; α-1 microglobulin
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Concentration
10mM
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Purity
99.5
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Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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UNC9994 (hydrochloride) [CAS 2108826-33-9]
UNC9994 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.