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USP28-IN-2 [CAS 2931509-11-2]
USP28-IN-2 [CAS 2931509-11-2]
SKU:QM-0068208
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Product Details
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Description
USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib.
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CAS Number
[2931509-11-2]
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Molecular Formula
C23H20Cl2N2O3S
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Molecular Weight
475.39
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Smiles
CS(=O)(C1=CC=C(C(Cl)=C1)C(NC2=CC=C(C(C3=CC=C(C=C3)C4(CC4)N)=C2)Cl)=O)=O
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Target
Deubiquitinase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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USP28-IN-2 [CAS 2931509-11-2]
USP28-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.