Utreloxastat [CAS 1213269-96-5]
Utreloxastat [CAS 1213269-96-5]
SKU:QM-0144181-01
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Product Details
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Description
Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of CYP1A2 and 2B6 with an IC50 of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc[1][2].
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CAS Number
[1213269-96-5]
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Molecular Formula
C18H28O2
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Molecular Weight
276.41
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Smiles
O=C1C(C)=C(C)C(C(C)=C1CCCCCCCCC)=O
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Target
Cytochrome P450; Ferroptosis; Lipoxygenase; α-synuclein
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Isoform
CYP1A2
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Purity
99.69
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Utreloxastat [CAS 1213269-96-5]
Utreloxastat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.