Vardenafil (hydrochloride trihydrate) [CAS 330808-88-3]
Vardenafil (hydrochloride trihydrate) [CAS 330808-88-3]
SKU:QM-0158336-01
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Product Details
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Description
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4[1]. Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels[2]. Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
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CAS Number
[330808-88-3]
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Molecular Formula
C23H39ClN6O7S
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Molecular Weight
579.11
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Smiles
O=C1N=C(C2=CC(S(=O)(N3CCN(CC)CC3)=O)=CC=C2OCC)NN4C1=C(C)N=C4CCC.Cl.O.O.O
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Target
Endogenous Metabolite; Phosphodiesterase (PDE)
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Isoform
PDE1; PDE3; PDE4; PDE5; PDE6
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Purity
99.67
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Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H373
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Precautions
H301, H373
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Vardenafil (hydrochloride trihydrate) [CAS 330808-88-3]
Vardenafil (hydrochloride trihydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.