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VEGFR-2/AKT-IN-2
VEGFR-2/AKT-IN-2
SKU:QM-0117810
Price on request
Quantity
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Product Details
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Description
VEGFR-2/AKT-IN-2 (Compound 5) is a VEGFR-2/AKT inhibitor (IC50: 0.061 μM for VEGFRin HepG2 cell) . VEGFR-2/AKT-IN-2 reduces total and phosphorylated AKT as well as up-regulates BAX and Caspase-3 and down-regulates Bcl-2 in cells, thereby promoting Apoptosis. VEGFR-2/AKT-IN-2 causes cell cycle arrest in S phase. VEGFR-2/AKT-IN-2 inhibits the growth of human liver tumor cells[1].
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Molecular Formula
C25H16FN5S
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Molecular Weight
437.49
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Smiles
CC1=CC=C(C=C1)C2=CSC(N/N=C3C4=NC5=CC=C(C=C5N=C4C6=C/3C=CC=C6)F)=N2
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Target
Akt; Apoptosis; Bcl-2 Family; Caspase; VEGFR
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Isoform
Bcl-2; Caspase 3; VEGFR2/KDR/Flk-1
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Shipping Conditions
Room temperature
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VEGFR-2/AKT-IN-2
VEGFR-2/AKT-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.