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VEGFR-2/BRAF-IN-1
VEGFR-2/BRAF-IN-1
SKU:QM-0066919
Price on request
Quantity
Request quote or documents
Product Details
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Description
VEGFR-2/BRAF-IN-1 (Compound 4b) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.049, 0.063 and 0.005 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-1 induces apoptosis and arrests the cell cycle mainly in the G1/S phase[1].
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Molecular Formula
C26H20Cl2F3N5O3S2
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Molecular Weight
642.5
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Smiles
O=C(NNC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O
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Target
Apoptosis; Raf; VEGFR
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Isoform
B-Raf; VEGFR2/KDR/Flk-1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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VEGFR-2/BRAF-IN-1
VEGFR-2/BRAF-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.