VEGFR-2/DHFR-IN-1 [CAS 2831498-15-6]
VEGFR-2/DHFR-IN-1 [CAS 2831498-15-6]
SKU:QM-0069389
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Product Details
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Description
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].
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CAS Number
[2831498-15-6]
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Molecular Formula
C20H18ClNO4
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Molecular Weight
371.81
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Smiles
O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
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Target
Bacterial; Dihydrofolate reductase (DHFR) ; Fungal; VEGFR
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Isoform
VEGFR2/KDR/Flk-1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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VEGFR-2/DHFR-IN-1 [CAS 2831498-15-6]
VEGFR-2/DHFR-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.