VEGFR-2-IN-67
VEGFR-2-IN-67
SKU:QM-0011459
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Product Details
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Description
VEGFR-2-IN-67 (Compound 6b) is an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2). Its IC50 values for MDA-231 and MCF-7 cell lines are 5.91 µM and 7.16 µM respectively, and its inhibitory effect on VEGFR-2 is comparable to that of Sorafenib (IC50 is 53.63 nM). VEGFR-2-IN-67 exerts significant anti-cancer activity through mechanisms such as inducing Apoptosis (the early apoptosis rate reaches 57.20%), arresting the cell cycle at the G1 phase, upregulating pro-apoptotic markers and downregulating Bcl-2. VEGFR-2-IN-67 can be used for research in the field of cancer[1].
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Molecular Formula
C21H22ClN5OS
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Molecular Weight
427.95
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Smiles
O=C(N1CCN(CC1)C2=NC=NC3=C2C4=C(CCCC4)S3)NC5=CC=CC(Cl)=C5
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Target
VEGFR
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Shipping Conditions
Room temperature
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VEGFR-2-IN-67
VEGFR-2-IN-67 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.