Vevorisertib (trihydrochloride) [CAS 1416775-08-0]
Vevorisertib (trihydrochloride) [CAS 1416775-08-0]
SKU:QM-0145991-01
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Product Details
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Description
Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors. Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT. Vevorisertib trihydrochloride has Kd values of 1.2 nM and 8.6 nM for AKT1 and AKT1-E17K, respectively. Vevorisertib trihydrochloride has IC50 values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. Vevorisertib trihydrochloride can be used for the research of cancer[1].
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CAS Number
[1416775-08-0]
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Molecular Formula
C35H41Cl3N8O
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Molecular Weight
696.11
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Smiles
NC1=C(C=CC=N1)C2=NC3=CC=C(C4=CC(N(CC5)CCC5N(C)C(C)=O)=CC=C4)N=C3N2C6=CC=C(C7(CCC7)N)C=C6.[H]Cl.[H]Cl.[H]Cl
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Target
Akt
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Isoform
Akt1; Akt2; Akt3
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Concentration
10mM
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Purity
99.13
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Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Vevorisertib (trihydrochloride) [CAS 1416775-08-0]
Vevorisertib (trihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.