Vimirogant (hydrochloride) [CAS 1802678-42-7]
Vimirogant (hydrochloride) [CAS 1802678-42-7]
SKU:QM-0083439-01
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Product Details
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Description
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM) . Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research[1][2].
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CAS Number
[1802678-42-7]
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Molecular Formula
C27H35F3N4O3S.xHCl
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Smiles
O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Cl.[x]
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Target
ROR
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Isoform
RORγ
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Purity
98.39
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Solubility
DMSO : 125 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Vimirogant (hydrochloride) [CAS 1802678-42-7]
Vimirogant (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.