Volasertib (trihydrochloride) [CAS 946161-17-7]
Volasertib (trihydrochloride) [CAS 946161-17-7]
SKU:QM-0060035-01
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Product Details
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Description
Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models[1][2].
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CAS Number
[946161-17-7]
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Molecular Formula
C34H53Cl3N8O3
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Molecular Weight
728.2
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Smiles
O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6.[H]Cl.[H]Cl.[H]Cl
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Target
Apoptosis; Polo-like Kinase (PLK)
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Isoform
PLK1; PLK2; PLK3
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Purity
99.12
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Solubility
H2O : ≥ 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Volasertib (trihydrochloride) [CAS 946161-17-7]
Volasertib (trihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.