VTP50469 (mesylate) [CAS 2169919-27-9]
VTP50469 (mesylate) [CAS 2169919-27-9]
SKU:QM-0108455
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Product Details
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Description
VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLL's chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.
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CAS Number
[2169919-27-9]
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Molecular Formula
C34H55FN6O10S3
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Molecular Weight
823.03
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Smiles
CS(=O)(O)=O.CC(C)N(C(C)C)C(C(C=C(C=C1)F)=C1OC2=CN=CN=C2N(C3)CC3(CC4)CCN4C[C@@H]5CC[C@H](CC5)NS(C)(=O)=O)=O.CS(=O)(O)=O
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Target
Apoptosis; Epigenetic Reader Domain
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Shipping Conditions
Room temperature
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VTP50469 (mesylate) [CAS 2169919-27-9]
VTP50469 (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.