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VU0469650 (hydrochloride)

VU0469650 (hydrochloride)

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SKU:QM-0053201

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  • Description

    VU0469650 hydrochloride is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) . VU0469650 hydrochloride inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50= 99 nM) . VU0469650 hydrochloride is promising for research of central nervous system diseases such as anxiety, addiction, and epilepsy[1].

  • Molecular Formula

    C22H29ClN4O

  • Molecular Weight

    400.94

  • Smiles

    O=C(N1[C@@H](CN(C2=C(N=CC=C2)C#N)CC1)C)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3.Cl

  • Target

    MGluR

  • Isoform

    MGluR1

  • Shipping Conditions

    Room temperature

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VU0469650 (hydrochloride)

VU0469650 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.