Xevinapant (hydrochloride) [CAS 1071992-57-8]
Xevinapant (hydrochloride) [CAS 1071992-57-8]
SKU:QM-0143830-01
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Product Details
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Description
Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs) . Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors[1][2].
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CAS Number
[1071992-57-8]
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Molecular Formula
C32H44ClN5O4
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Molecular Weight
598.18
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Smiles
O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl
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Target
Apoptosis; IAP
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Isoform
CIAP-1; cIAP-2; XIAP
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Purity
98.01
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Solubility
DMSO : 175 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Xevinapant (hydrochloride) [CAS 1071992-57-8]
Xevinapant (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.