Y-27632-d4 (hydrochloride hydrate)
Y-27632-d4 (hydrochloride hydrate)
SKU:QM-0052778
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Product Details
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Description
Y-27632-d4 hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate. Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5][6][7].
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Molecular Formula
C14H21D4Cl2N3O2
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Molecular Weight
342.3
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Smiles
O=C([C@H]1CC[C@@](CC1)([C@H](N)C)[H])NC2=C([2H])C([2H])=NC([2H])=C2[2H].O.Cl.Cl
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Target
Apoptosis; Isotope-Labeled Compounds; ROCK
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Shipping Conditions
Room temperature
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Y-27632-d4 (hydrochloride hydrate)
Y-27632-d4 (hydrochloride hydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.