Y-27632 (hydrochloride hydrate) [CAS 331752-47-7]
Y-27632 (hydrochloride hydrate) [CAS 331752-47-7]
SKU:QM-0079622
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Product Details
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Description
Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5][6][7].
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CAS Number
[331752-47-7]
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Molecular Formula
C14H25Cl2N3O2
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Molecular Weight
338.27
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Smiles
O=C([C@H]1CC[C@](CC1)([H])[C@H](N)C)NC2=CC=NC=C2.Cl.O.Cl
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Target
Apoptosis; Organoid; ROCK
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H312-H332
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Y-27632 (hydrochloride hydrate) [CAS 331752-47-7]
Y-27632 (hydrochloride hydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.