YM-202074 (fumarate) [CAS 299900-84-8]
YM-202074 (fumarate) [CAS 299900-84-8]
SKU:QM-0083379-01
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Product Details
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Description
YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
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CAS Number
[299900-84-8]
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Molecular Formula
C56H72N8O16S2
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Molecular Weight
1177.34
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Smiles
OC(/C=C/C(O)=O)=O.CN(C1CCCCC1)C(C2=CN3C4=CC(CN(C)CCOC)=CC=C4N=C3S2)=O.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O.CN(C5CCCCC5)C(C6=CN7C8=CC(CN(C)CCOC)=CC=C8N=C7S6)=O
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Target
MGluR
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Isoform
MGluR1
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Shipping Conditions
Room temperature
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Hazard Statement
H301-H319
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Precautions
P264-P270-P280-P305+P351+P338-P330-P405-P501
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YM-202074 (fumarate) [CAS 299900-84-8]
YM-202074 (fumarate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.