YM-244769 (hydrochloride) [CAS 837424-39-2]
YM-244769 (hydrochloride) [CAS 837424-39-2]
SKU:QM-0112670-01
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Product Details
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Description
YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].
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CAS Number
[837424-39-2]
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Molecular Formula
C26H23ClFN3O3
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Molecular Weight
479.93
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Smiles
O=C(C1=CN=C(C=C1)OC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)NCC4=CC(N)=CC=C4.[H]Cl
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Target
Na+/Ca2+ Exchanger
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Purity
99.02
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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YM-244769 (hydrochloride) [CAS 837424-39-2]
YM-244769 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.