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Z-VAD-FMK (GMP) [CAS 161401-82-7]

Z-VAD-FMK (GMP) [CAS 161401-82-7]

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QM-0008296

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Product Details

  • Description

    Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1) . Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis[1][2][3][4][5][6][7].

  • CAS Number

    [161401-82-7]

  • Molecular Formula

    C21H28FN3O7

  • Molecular Weight

    453.46

  • Smiles

    O=C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CF)=O)=O)=O)C(C)C)OCC1=CC=CC=C1

  • Target

    Apoptosis; Caspase

  • Shipping Conditions

    Room temperature
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Z-VAD-FMK (GMP) [CAS 161401-82-7]

Z-VAD-FMK (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.