1α-Hydroxyvitamin D5 [CAS 187935-17-7]
1α-Hydroxyvitamin D5 [CAS 187935-17-7]
SKU:QM-0006402
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Product Details
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Description
1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease[1].
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CAS Number
[187935-17-7]
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Molecular Formula
C29H48O2
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Molecular Weight
428.69
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Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
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Target
COX; FAK; Interleukin Related; Myosin
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Isoform
COX-2; IL-1
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Shipping Conditions
Room temperature
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1α-Hydroxyvitamin D5 [CAS 187935-17-7]
1α-Hydroxyvitamin D5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.