25,26-Dihydroxyvitamin D3 [CAS 29261-12-9]
25,26-Dihydroxyvitamin D3 [CAS 29261-12-9]
SKU:QM-0152532-01
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Product Details
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Description
25,26-Dihydroxyvitamin D3 (25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. IC50 value: Target: VD metabolite The biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.
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CAS Number
[29261-12-9]
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Molecular Formula
C27H44O3
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Molecular Weight
416.64
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Smiles
C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C(CC[C@H](O)C\3)=C)CCCC(O)(C)CO
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Target
Endogenous Metabolite; VD/VDR
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Isoform
Human Endogenous Metabolite
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Purity
97.93
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H331, H373, H410
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Precautions
H301, H331, H373, H410
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25,26-Dihydroxyvitamin D3 [CAS 29261-12-9]
25,26-Dihydroxyvitamin D3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.