Autophagy agonist-1
Autophagy agonist-1
SKU:QM-0009771
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Product Details
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Description
Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells[1].
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Molecular Formula
C33H41N3O5
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Molecular Weight
559.7
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Smiles
O=C1C2[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@](C=C(C)[C@@H]4OCC5=NN=C(/C=C/C6=CC=C(N(C)C)C=C6)O5)1[C@]4(O)[C@H](O)C(C)=C2
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Target
Atg8/LC3; Autophagy; CDK; PINK1/Parkin
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Isoform
CDK4
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Shipping Conditions
Room temperature
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Autophagy agonist-1
Autophagy agonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.