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Bcl-2-IN-22
Bcl-2-IN-22
SKU:QM-0117435
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Product Details
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Description
Bcl-2-IN-22 (compound 1) is a gold (I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL-2[1].
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Molecular Formula
C38H46AuF6N8P
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Molecular Weight
956.76
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Smiles
CC1=CC(C)=CC(C)=C1[N]2=NC([Au+]C3N=[N](C4=C(C)C=C(C)C=C4C)N=[N]3C5=C(C)C=C(C)C=C5C)[N](C6=C(C)C=C(C)C=C6C)=N2.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Target
Apoptosis; Bcl-2 Family
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Shipping Conditions
Room temperature
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Bcl-2-IN-22
Bcl-2-IN-22 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.