Bcl-2-IN-23
Bcl-2-IN-23
SKU:QM-0013717
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Product Details
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Description
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting Bcl-2. The IC50 of Bcl-2-IN-23 in HTB-140, HeLa and SW620 cells is 25.7-33.7 μM. Bcl-2-IN-23 can non-covalently competitively bind to Bcl-2 protein, significantly reduce its expression, and induce late apoptosis and necroptosis of cancer cells. Bcl-2-IN-23 enhances the sensitivity of cancer cells to apoptosis and reduces the release of IL-6 inflammatory factors by disrupting the Bcl-2-mediated mitochondrial apoptosis inhibition pathway. Bcl-2-IN-23 can be used for anti-apoptosis research of malignant tumors such as melanoma, cervical cancer, and colorectal cancer[1].
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Molecular Formula
C32H32N10O2
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Molecular Weight
588.66
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Smiles
COC1=CC(C2=CC=C(NC3=NN=NN3CCC4=CC=CC=C4)C(OC)=C2)=CC=C1NC5=NN=NN5CCC6=CC=CC=C6
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Target
Apoptosis; Bcl-2 Family; Necroptosis
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Isoform
Bcl-2
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Shipping Conditions
Room temperature
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Bcl-2-IN-23
Bcl-2-IN-23 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.