Bcl-2-IN-7 [CAS 3027734-46-6]
Bcl-2-IN-7 [CAS 3027734-46-6]
SKU:QM-0066015
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Product Details
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Description
Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively[1].
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CAS Number
[3027734-46-6]
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Molecular Formula
C24H22N4O5S2
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Molecular Weight
510.59
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Smiles
O=C(NC1=CC=CC=C1C)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O
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Target
Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53
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Isoform
Bax; Bcl-2; Caspase 7
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Bcl-2-IN-7 [CAS 3027734-46-6]
Bcl-2-IN-7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.