Fasudil (dihydrochloride) [CAS 203911-27-7]
Fasudil (dihydrochloride) [CAS 203911-27-7]
SKU:QM-0057347-01
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Product Details
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Description
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator[1][2][3].
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CAS Number
[203911-27-7]
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Molecular Formula
C14H19Cl2N3O2S
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Molecular Weight
364.29
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Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.[H]Cl.[H]Cl
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Target
Autophagy; Calcium Channel; HIV; PKA; PKC; ROCK
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Isoform
PKA; PKC; ROCK1; ROCK2
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Purity
99.98
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Solubility
DMSO : 20.83 mg/mL (ultrasonic) |H2O : 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Fasudil (dihydrochloride) [CAS 203911-27-7]
Fasudil (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.