Ferroptosis inducer-9
Ferroptosis inducer-9
SKU:QM-0013353
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Product Details
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Description
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe (II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) [1].
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Molecular Formula
C21H18N2O5S
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Molecular Weight
410.44
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Smiles
O=C(C1=CN(C2=NC=CS2)C=C1C3=CC=CO3)C4=CC(OC)=C(OC)C(OC)=C4
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Target
COX; Ferroptosis; Glutathione Peroxidase; Microtubule/Tubulin
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Isoform
GPX4
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Shipping Conditions
Room temperature
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Ferroptosis inducer-9
Ferroptosis inducer-9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.
Learn how iron-dependent lipid oxidation, GPX4 defenses, and off-target effects can influence interpretation of ferroptosis experiments. Explore the ferroptosis experimental design guide ↗