αMβ2 integrin agonist-1
αMβ2 integrin agonist-1
SKU:QM-0013016
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Product Details
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Description
αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC50=1.4 nM) . αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis) [1].
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Molecular Formula
C14H16F3N3O7
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Molecular Weight
395.29
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Smiles
[NH3+]C1=CC=C(C=C1)CNC(N[C@H](C(O)=O)CC(O)=O)=O.O=C([O-])C(F)(F)F
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Target
ERK; Integrin; JNK
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Shipping Conditions
Room temperature
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αMβ2 integrin agonist-1
αMβ2 integrin agonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.