P53 Activator 16
P53 Activator 16
SKU:QM-0016071
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Product Details
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Description
P53 Activator 16 (Compound JC16) is a p53 activator. P53 Activator 16 exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity towards p53-Y220C mutant cancer cells, while having little effect on wild-type or P53-deficient cells. P53 Activator 16 induces the conformational transition of cell p53-Y220C from the mutant form to the wild-type form, accompanied by the transcriptional activation of p53 target genes, without increasing the overall level of p53 protein. P53 Activator 16 can be used for the study of p53 mutant cancers[1].
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Molecular Formula
C15H17N5O2
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Molecular Weight
299.33
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Smiles
CN(C)CCN1N=C(N2C=CC=C2)C3=CC([N+]([O-])=O)=CC=C31
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Target
Apoptosis; MDM-2/p53
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Shipping Conditions
Room temperature
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P53 Activator 16
P53 Activator 16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.