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P53 Activator 17
P53 Activator 17
SKU:QM-0016072
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Product Details
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Description
P53 Activator 17 is a p53-Y220C activator. p53 Activator 17 exhibits selective cytotoxicity and pro-apoptotic activity in p53-Y220C mutant cancer cell lines, with minimal effects in wild-type or p53-null cells. p53 Activator 17 induces a mutant-to-wild-type conformational shift in cellular p53-Y220C, accompanied by transcriptional activation of canonical p53 target genes, including BBC3 (PUMA) and MDM2. p53 Activator 17 can be used for the study of hepatocellular carcinoma and breast cancer[1].
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Molecular Formula
C15H17BrN4
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Molecular Weight
333.23
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Smiles
BrC1=CC=C2C(C(N3C=CC=C3)=NN2CCN(C)C)=C1
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Target
Apoptosis; MDM-2/p53
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Shipping Conditions
Room temperature
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P53 Activator 17
P53 Activator 17 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.