P53 Activator 2 [CAS 2338764-89-7]
P53 Activator 2 [CAS 2338764-89-7]
SKU:QM-0066590
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Product Details
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Description
P53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].
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CAS Number
[2338764-89-7]
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Molecular Formula
C20H21N5O2
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Molecular Weight
363.41
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Smiles
NCCCCNC1=NC(/C=C/C2=CC=C([N+]([O-])=O)C=C2)=NC3=C1C=CC=C3
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Target
Apoptosis; DNA/RNA Synthesis; MDM-2/p53
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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P53 Activator 2 [CAS 2338764-89-7]
P53 Activator 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.