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PARP/EZH2-IN-2
PARP/EZH2-IN-2
SKU:QM-0073328
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Product Details
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Description
PARP/EZH2-IN-2 (compound 12e) is a dual target PARP1 and EZH2 inhibitor, with IC50 values of 6.89 and 27.34 nM, respectively. PARP/EZH2-IN-2 shows anticancer activity, with no toxicity to normal cells. PARP/EZH2-IN-2 achieves synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induces cell death by regulating excessive autophagy[1].
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Molecular Formula
C33H31N7O3
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Molecular Weight
573.64
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Smiles
CC1=CC(C)=C(C(N1)=O)CNC(C2=CC(C3=CC=C(C4=NC5=C(C(N)=O)C=CC=C5N4)C=C3)=CC6=C2C=NN6C(C)C)=O
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Target
Histone Methyltransferase; PARP
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Isoform
EZH2; PARP1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PARP/EZH2-IN-2
PARP/EZH2-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.