PARP/VEGFR3-IN-1
PARP/VEGFR3-IN-1
SKU:QM-0015664
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Product Details
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Description
PARP/VEGFR3-IN-1 (Compound 18) is a dual PARP-VEGFR3 target inhibitor. Its IC50 values for PARP1, PARP2, and VEGFR3 are 0.0763, 0.0366, and 4.25 nM respectively. PARP/VEGFR3-IN-1 has no inhibitory effect on VEGFR1/2 and shows subtype selectivity. PARP/VEGFR3-IN-1 exhibits significant anti-proliferative activity in various cancer cells (leukemia, lung cancer, and triple-negative breast cancer) . PARP/VEGFR3-IN-1 induces DNA damage and cell cycle arrest. PARP/VEGFR3-IN-1 triggers various forms of cell death by inducing apoptosis and autophagy. PARP/VEGFR3-IN-1 can be formulated into nanodelivery systems, significantly enhancing tumor targeting and therapeutic window[1].
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Molecular Formula
C38H33FN8O5
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Molecular Weight
700.72
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Smiles
COC1=CC=C(C2=NC=NC3=C2C=C(OC)C(OCCCN4C=C(CNC(C5=CC(CC6=NNC(C7=C6C=CC=C7)=O)=CC=C5F)=O)N=N4)=C3)C=C1
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Target
Apoptosis; Autophagy; DNA/RNA Synthesis; PARP; VEGFR
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Isoform
PARP1; PARP2; VEGFR3/Flt-4
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Shipping Conditions
Room temperature
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PARP/VEGFR3-IN-1
PARP/VEGFR3-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.