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PARP1-IN-27
PARP1-IN-27
SKU:QM-0107942
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Product Details
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Description
PARP1-IN-27 (Compound 9B) is the inhibitor for PARP1 and PARP2, with IC50 of 2.53 nM and 6.45 nM in cell SUM149PT. PARP1-IN-27 inhibits the proliferation of BRCA-mutated cancer cells SUM149PT, HCC1937 and Capan-1, with IC50 of 0.62, 1.91 and 4.26 μM respectively. PARP1-IN-27 aggravates DNA double-strand breaks, increases ROS generation, arrests cell cycle at G2/M phase, and induces apoptosis in SUM149PT[1].
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Molecular Formula
C17H12FNO4
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Molecular Weight
313.28
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Smiles
O=C1C(C2=CC=CC(OC)=C2)=CC3=CC(F)=CC(C(N)=O)=C3O1
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Target
Apoptosis; PARP; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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PARP1-IN-27
PARP1-IN-27 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.