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(Rac) -PROTAC PARP/EGFR ligand 1 [CAS 2935073-36-0]

(Rac) -PROTAC PARP/EGFR ligand 1 [CAS 2935073-36-0]

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QM-0064827

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Product Details

  • Description

    (Rac) -PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP) . (Rac) -PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. (Rac) -PROTAC PARP/EGFR ligand 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

  • CAS Number

    [2935073-36-0]

  • Molecular Formula

    C53H56ClF2N9O8

  • Molecular Weight

    1020.52

  • Smiles

    O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCNC(C(COCC#C)NC(CCCCCOC4=CC5=C(NC6=CC=C(C(Cl)=C6)F)N=CN=C5C=C4OC)=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7

  • Target

    Target Protein Ligand-Linker Conjugates

  • Solubility

    10 mM in DMSO

  • Shipping Conditions

    Room temperature
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Variant Variant total Quantity Price Variant total
1 EachQM-0064827
1 EachQM-0064827
£0.00/ea		 £0.00
£0.00/ea £0.00

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(Rac) -PROTAC PARP/EGFR ligand 1 [CAS 2935073-36-0]

(Rac) -PROTAC PARP/EGFR ligand 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.