Rel-PROTAC PARP1 degrader
Rel-PROTAC PARP1 degrader
SKU:QM-0138380-01
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Product Details
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Description
Rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader. ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
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Molecular Formula
C58H63Cl2N11O10
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Molecular Weight
1145.09
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Smiles
O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O
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Target
PARP; PROTACs
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Purity
98.99
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Solubility
DMSO : 110 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Rel-PROTAC PARP1 degrader
Rel-PROTAC PARP1 degrader is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.