15 (R) -15-Methyl prostaglandin D2 [CAS 210978-26-0]
15 (R) -15-Methyl prostaglandin D2 [CAS 210978-26-0]
SKU:QM-0096746-01
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Product Details
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Description
15 (R) -15-Methyl prostaglandin D2 (15 (R) -15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15 (R) -15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15 (R) -15-methyl PGD2 is >10 μM.
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CAS Number
[210978-26-0]
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Molecular Formula
C21H34O5
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Molecular Weight
366.49
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Smiles
CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O
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Target
Prostaglandin Receptor
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Purity
98
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Storage Conditions
Solution, -20°C, 2 years
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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15 (R) -15-Methyl prostaglandin D2 [CAS 210978-26-0]
15 (R) -15-Methyl prostaglandin D2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.