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γ-Secretase modulator 12 [CAS 2204249-82-9]
γ-Secretase modulator 12 [CAS 2204249-82-9]
SKU:QM-0066640
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Product Details
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Description
γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM) . γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].
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CAS Number
[2204249-82-9]
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Molecular Formula
C25H23N3O2
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Molecular Weight
397.47
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Smiles
O=C1C2=C(CN1CC)C=C(C3=C(C)N=C4C(OCC5=CC=CC=C5)=CC=CN43)C=C2
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Target
Amyloid-β; γ-secretase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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γ-Secretase modulator 12 [CAS 2204249-82-9]
γ-Secretase modulator 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.