5-HT2A receptor agonist-13
5-HT2A receptor agonist-13
SKU:QM-0015706
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Product Details
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Description
5-HT2A receptor agonist-13 (Compound 28c) is a partial agonist of the 5-HT2A receptor, with an EC50 value of 416.9 nM and a Ki value of 113.9 nM. 5-HT2A receptor agonist-13 exhibits very weak agonistic activity towards the 5-HT2B receptor (EC50 = 120.2 nM), D2 receptor (Ki = 1298 nM), and has no activity towards the 5-HT2C receptor. 5-HT2A receptor agonist-13 exhibits weak inhibitory activity on the serotonin transporter (SERT) (EC50 = 977.2 nM) . 5-HT2A receptor agonist-13 has antidepressant activity in mouse models and does not induce hallucinogenic behavior. 5-HT2A receptor agonist-13 can be used for the study of major depressive disorder (MDD) and treatment-resistant depression (TRD) [1].
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Molecular Formula
C21H23N3O
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Molecular Weight
333.43
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Smiles
COC1=CC=CC(CCN2CCC=C(C2)C3=CNC4=C3C=CC=N4)=C1
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Target
5-HT Receptor; Dopamine Receptor; Serotonin Transporter
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Isoform
5-HT2 Receptor; D2 Receptor
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Shipping Conditions
Room temperature
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5-HT2A receptor agonist-13
5-HT2A receptor agonist-13 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.