5-HT2B antagonist-2
5-HT2B antagonist-2
SKU:QM-0010398
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Product Details
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Description
5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases[1].
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Molecular Formula
C23H28Cl2N4O7S
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Molecular Weight
575.46
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Smiles
O=C(O)[C@@H](N)CCC(N1C[C@@H](NS(=O)(C2=CC=C(OC)C(C(NC3=CC=CC=C3Cl)=O)=C2)=O)CC1)=O.Cl
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Target
5-HT Receptor
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Isoform
5-HT2 Receptor
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Shipping Conditions
Room temperature
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5-HT2B antagonist-2
5-HT2B antagonist-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.