A2AR modulator-1 [CAS 3007566-23-3]
A2AR modulator-1 [CAS 3007566-23-3]
SKU:QM-0009731
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Product Details
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Description
A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A2a receptor (A2aR) modulator with an IC50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4+ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models[1].
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CAS Number
[3007566-23-3]
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Molecular Formula
C23H20N6
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Molecular Weight
380.45
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Smiles
N#CC1=C(C2=CC=CC(C3=CC=CN=C3)=C2)C(C#N)=C(N4CCCCC4)N=C1N
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Target
Adenosine Receptor
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Isoform
Adenosine A2A receptor (A2AR)
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Shipping Conditions
Room temperature
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A2AR modulator-1 [CAS 3007566-23-3]
A2AR modulator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.