Adenosine receptor antagonist 6 [CAS 2913578-04-6]
Adenosine receptor antagonist 6 [CAS 2913578-04-6]
SKU:QM-0012922
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Product Details
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Description
Adenosine receptor antagonist 6 is an orally active and selective A2A adenosine receptor (A2AAR) antagonist, with a Ki of 19.18 nM. Adenosine receptor antagonist 6 inhibits 5’-N-ethylcarboxamide adenosine (NECA) -mediated cAMP production (IC50 = 0.089 μM) and immunosuppression, while promoting IL-2 and IFN-γ secretion. Adenosine receptor antagonist 6 abolishes the immunosuppressive effects of adenosine on T-cell activation and cytokine release. Adenosine receptor antagonist 6 inhibits tumor growth in a CT26/MC38 xenograft model. Adenosine receptor antagonist 6 can be used for the study of colon cancer[1].
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CAS Number
[2913578-04-6]
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Molecular Formula
C18H16N6O
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Molecular Weight
332.36
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Smiles
O=C(C1=CN2C3=CC=CC=C3N=C2C(N)=N1)N[C@@H](C)C4=NC=CC=C4
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Target
Adenosine Receptor; Cytochrome P450; IFNAR; Interleukin Related
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Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)
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Shipping Conditions
Room temperature
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Adenosine receptor antagonist 6 [CAS 2913578-04-6]
Adenosine receptor antagonist 6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.