AHR agonist 10 [CAS 1191937-43-5]
AHR agonist 10 [CAS 1191937-43-5]
SKU:QM-0014960
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Product Details
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Description
AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM) . AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research[1].
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CAS Number
[1191937-43-5]
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Molecular Formula
C18H20O3
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Molecular Weight
284.35
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Smiles
CC(C1=C(C=C(C=C1O)/C=C/C2=CC=C(C=C2)OC)O)C
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Target
Aryl Hydrocarbon Receptor; Cytochrome P450; Interleukin Related
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Isoform
IL-6; IL-8
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Shipping Conditions
Room temperature
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AHR agonist 10 [CAS 1191937-43-5]
AHR agonist 10 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.