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ALK/ROS1-IN-5
ALK/ROS1-IN-5
SKU:QM-0009295
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Quantity
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Product Details
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Description
ALK/ROS1-IN-5 (compound X4) is a selective ALK and ROS1 kinases inhibitor with IC50s of 0.512 μM (ALK), 0.766 μM (ROS1), respectively. ALK/ROS1-IN-5 inhibits H2228 cells with an IC50 of 0.034 μM. ALK/ROS1-IN-5 induces cancer cells apoptosis in dose-dependent manner. ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells[1].
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Molecular Formula
C32H28F2N4O3
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Molecular Weight
554.59
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Smiles
FC1=CC(F)=CC(CC2=CC=C(NN=C3NC(C4=CC=C(C5=CC=C(OC)C=C5)C=C4N6CCOCC6)=O)C3=C2)=C1
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Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; ROS Kinase
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Shipping Conditions
Room temperature
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ALK/ROS1-IN-5
ALK/ROS1-IN-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.